Maimon Lab
Tuning Neural Stem Cells
Our Mission
At the Maimon Lab, we believe that science - like music, art, and nature - is a form of creative expression. Inspired by the rhythm of neural circuits, the harmony of stem cell dynamics, and the delicate balance between degeneration and regeneration, we aim to reprogram the brain to heal.
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Our mission is to pioneer regenerative strategies for neurodegenerative diseases by unlocking the potential of in vivo cellular identity conversion. Through bold experimentation and interdisciplinary thinking, we explore how dormant neural stem cells can be reawakened and guided to form new glial and neurons, with the ultimate goal of inducing brain regeneration.
We are here to:​
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Push the fields of adult neurogenesis, neural stem cells and in vivo cellular reprogramming
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Transform neurodegeneration including Huntington's Disease into a set of treatable conditions
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Mentor the next generation of scientists who see science as both a craft and a calling
The brain is not static. It’s a symphony, and we are here to compose a new movement.
Engineering Neuro Cell Biology
We are developing therapeutic approaches to reactivate and reprogram brain cells in vivo. Recently we demonstrated that by single injection of DNA drug (Antisense Oligonucleutids - ASOs) to suppress the RNA binding protein PTBP1 we can reactivate dormant neural stem cells to become new straiatal neurons in the aging brain.
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Tools that currently define our lab are: human iPSC and organoid systems, microfluidic chambers, mouse models of disease, CRISPR/CAS9, single nuclear sequencing and single cell spatial transcriptomics/ proteomics platforms for decoding cell identity in space.
Our lab exists to bridge intuition with evidence, engineering with biology, and ideas with impact.
Mentorship and Teaching Philosophy
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1. Critical Thinking
Critical thinking involves questioning assumptions, engaging in dialogue, and reflecting on one’s own thought processes.
We help students develop this skill by encouraging skepticism toward disciplinary norms and incorporating perspectives from other fields.
2. Intellectual Diversity
A positive learning environment respects different learning styles and backgrounds. We adapt varied methods - lectures, readings, visuals, and activities - and take interest in students’ cultural and personal contexts to support diverse ways of learning.
3. Clear Standards
From day one, we set clear academic and behavioral expectations. We explain the rationale behind each standard and provide detailed instructions. I also hold myself to high standards by preparing thoroughly for every class and lab session.
4. Transparency
I believe in mutual evaluation and frequent feedback. Student feedback should be prompt, clear, and consistent, helping them align with expectations. I regularly collect and apply feedback to improve the learning and lab life experience.
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We support trainees in defining their long-term career goals and help them map a clear path to achieve them. We work closely with each individual to identify their strengths and areas for growth, encouraging them to build on what they do best while steadily improving their weaknesses. I respect each trainee’s unique qualities and tailor project goals accordingly.
Diversity
Our lab represents diversity and inclusion in at least three ways. As an immigrant, scientist-parent, and musician, I bring perspectives that are minorities in science and exceedingly under-represented amongst faculty members. Our lab participates in programs and organizations that support students and trainees from diverse backgrounds, particularly those from under-represented categories to openly and safely express their ideas against implicit and explicit biases. As my friends and family often seek advice from me due to my non-judgmental nature, I endeavor to cultivate a similar environment of acceptance among my students and colleagues.
Contact
+1 (858) 2959921